Can be easily farmed from the Hoplites at the very beginning of The Lord's Path 1 - 2, after Phalanx has been defeated.On the inside of the shield was a form of double grip. While it cannot be upgraded, this shield's statistics are identical to a Purple Flame Shield +3, with a lower Strength requirement to wield. If you don't want to spend resources upgrading the Purple Flame Shield, or don't meet its stat requirements, this shield is strictly superior. Crucial to the hoplite shield design was the concave, bowl shape of the shield.Despite the text in its item description, this shield is a Large Shield, not a Standard Shield. Only available in Demon's Souls Remake.Trade Rune Shield to Sparkly the Crow to receive this item.Rare Hoplite drop at Gates of Boletaria 1 - 1 in the stairs on the right before the boss fog and at The Lord's Path 1 - 2 before the bridge.The legions' protective formation was renowned across the kingdom. The reinforced center of the shield is ideal against direct attacks. This type of shield works best at reducing damage or guarding, and cannot be used to parry.Ī medium-sized metal shield, specifically designed for Boletarian Legions. Large Shields provide a greater value for blocking and protecting one's self from enemy attacks, but their great weight uses more of the player's Equip Burden and may decrease the player's mobility. They persisted during the middle ages as the buckler and the last use of a shield in battle by westerners was the Scottish Highlander targe which was a small round shield.The Hoplite Shield is a Large Shield in Demon's Souls Remake. Whatever the reason, the shield came full circle by the end of the western Roman Empire and round shields became the norm again. Sparta produced one of the most iconic armies in ancient history and was renowned for its soldiers skill, discipline, professionalism and bravery. after Sparta helped form the Hellenic Union. It also needs to be considered that finances played a role in ancient battles as much as today and attempts to keep costs down were undertaken so some societies only had a greave on the left leg as that was the leg most likely to be forward. The military city-state of Sparta was founded around 900 B.C and reached its pinnacle of power in 481 B.C. Something else to consider is that a common method of fighting was the spear held over the head and used in a downward stabbing motion, the legs wouldn't be in much danger in mass combat. How that influenced the famous Greek shield we can only speculate.Įlongated or oval shields did become very common during the iron age and the Greeks themselves adopted a type they called the thyreos which they possibly copied from the Romans. The bronze age saw the dominance of geometric art which was squares, lozenges, zigzags and also concentric circles. Hoplite shield design was incredibly varied. Smaller flatter round shields do appear in other parts of Europe during the bronze age and it could be something as simple as you can trace the outline of a shield with a simple compass made of a scribe attached to a piece of string. It can't be answered with any certainty as it likely had a cultural reason, the same way the earlier figure of 8 shields used by the Mycenaeans might seem an odd choice. These Hoplite shields, Spartan shields, and Trojan shields come in fully functional and decorative designs. The gladius' short reach, combined with the necessity to get up close and personal to use the shield as a primary weapon, means a larger shield (curved to fit around the body, works better. The gladius is strictly a thrusting weapon, so restriction of arm movements is no longer of significance. The opponent is mauled by the shield, it's top edge and boss in particular used to wear an opponent down until his guard drops and the gladius can be slipped under his ribs. The greater reach of the spear also keeps the opponent at bay, so less defensive coverage is necessary.įor Roman Legionnaires of the classic period, the shield is actually the primary weapon, the gladius (short sword) secondary. Because of the many different ways in which a spear was used by a hoplite in offence, in and out of formation, a lighter round shield was more suitable by providing less interference with the spear use. For a hoplite, the spear is the primary weapon and the shield only a secondary weapon, being primarily defensive.
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Is there a better alternative?ĭepending on the selection of features you require from your IDE, you might have better results with IntelliJ IDE, which is said to be lighter, more feature-rich, and even more customizable. On the Eclipse website, you’ll find further versions of the installer for different coding languages. You can install Eclipse on Windows, Mac, and Linux. All of this extra help checking errors and facilitating work is hugely popular with users and one of the main reasons Eclipse remains at the top of its class, despite the fact that it’s a bona fide development grandpa. It also comfortably supports most of the Java servers and offers code completion, syntax checking, and great support for refactoring your applications. It’s fast, but it also identifies errors as you type, making work faster and more fluid. One of the most popular Eclipse features is its built-in incremental compiler. In a step above and beyond many other tools, there are also old-school touches like a mailing list and IRC (chat), as well as frequent in-person events and a project repository that users can get involved in. On the Eclipse website itself, you’ll find documentation, getting-started guides, a wiki, newsletters, and blogs and videos. Given the way Eclipse is set up - and the skill set of the people likely to be using it - it’s also possible to create your own plug-ins if you feel that there’s a missing feature.Īs Eclipse is used by so many and has been around for so long, there’s some excellent help available. Any extra functionality you might need can be added via plug-ins, of which there are many, and optimized via the customizable layout which will allow you to make visual changes, including having more than one project running at any given time. In some cases, this will be aesthetic, but for many developers, it offers new possibilities when organizing and working with code.Įclipse was originally a Java tool but over the years has changed to allow development in a pretty wide variety of languages. Once it’s up and running, you’ll see that the choice Eclipse offers in functionality is mirrored in appearance, as the app has a completely customizable interface that can be rearranged to your liking. The IDE can also be used by Java EE, Java, C++, and PHP developers (and more) by paying attention during the set-up phase and picking the desired option while the application installer is in action. But Eclipse’s flexibility doesn’t end there. It’s also a flexible tool that’s available for Windows, Mac, and Linux, and there are dozens of installation options tailored to all kinds of developers. Part of Eclipse’s popularity is down to the fact that it’s free and open-source. Java has been around for decades, but it’s still extremely widely used and enables an amazing variety of devices - from super servers to set-top boxes - to run exactly as we need them to. It’s not the fastest, but Eclipse offers a solid range of function and featureĮclipse is one of the all-time most popular integrated development environments for Java available today. An older app that’s holding its own among the young guns Internet Download Manager can connect to the Internet at a set time, download the files you want, disconnect, or shut down your computer when it's done. You can also minimize this button in "Options→General tab→Customize download panel in browsers" IDM dialog.ĭownload files from your favorite web sitesĪfter installing "IDM integration module" browser extension, just continue surfing the Internet, and you will be amazed how easy is to download everything you want from your favorite web sites with IDM video download panel. When several links are selected with a mouse in a browser, IDM will show "Download with IDM" button. You need always to keep IDM extensions installed and enabled in browsers to take over downloads from the browsers and to have IDM's right click menu items! If you have any problem, first check that "IDM integration module" extension is installed and enabled in your browser. IDM offers the installation of its extensions for Chrome, Firefox, old and new Edge, Opera and other browsers. We develop browser extensions since 1999, and we have the best engineering solutions available today. IDM integrates seamlessly into Google Chrome, Firefox, Microsoft Edge, Opera, Safari, Internet Explorer, AOL, MSN, Maxthon and all other popular browsers. Our engineers have a lot of experience in download acceleration, and we constantly improve this download engine since 1999. Unlike other download managers and accelerators, IDM segments downloaded files dynamically during download process, and it reuses available connections without additional connect and login stages to achieve the best possible acceleration performance. IDM will accelerate downloads all times because of its innovative dynamic file segmentation technology. Our powerful download engine uses unique algorithms to receive Internet data in a fastest possible way. IDM will also repair broken and resume interrupted downloads due to lost connections, network problems, computer shutdowns, or unexpected power outages. You will be truly amazed how fast IDM downloads your files. Install Internet Download Manager (IDM) to stop waiting for your downloads. Internet Download Manager (IDM) is a tool to increase download speeds by up to 5 times, resume and schedule downloads. The North American paper sizes are based on traditional formats with arbitrary aspect ratios. Read more about common envelope sizes and styles. A DL format envelope will accommodate an A4 sheet folded in thirds or an A5 sheet folded in half lengthwise. Another commonly used format is the DL format. This works with the B and C envelope formats. The same method works for filing larger paper sizes in file folders of a smaller size. So if you have a C4 or B4 envelope and a sheet of A2 paper, you should fold it in half twice. The difference in the number of the page sizes equals the number of times you should fold it. This can be done by simply folding the larger papers in half (crease parallel to the shorter sides) until you reach the desired size. The consistent aspect ratio of the ISO papers makes it easy to fit larger paper sizes into smaller envelopes. Below is a table of the magnification factors between the most common A sizes in case the copiers at your local library do not have such presets. This eliminates wasted margins and saves you the trouble of trying to guess the right magnification factor, which can lead to a heap of misspent paper. These presets typically take the form of buttons labelled A3→A4 and so forth. Many copy machines have preset magnification factors for enlarging or reducing a copied document in order to print it on a different paper size. ISO Tips to Save You Time Simplified Enlargement and Reduction All of them have a height-to-width ratio equal to the square root of two. Below are tables with the dimensions of all three series. The C sizes are just between the A and B series. That is, a sheet of A4 easily fits into a C4 envelope. The sizes of the A series fit in C series envelopes of the same number. The C series was introduced to provide an envelope with enough space for an A series sheet. For example, B4 is between A3 and A4 in size, and B5 is between A4 and A5. The B paper sizes are a bit larger than their A series counterparts and are based on the geometric mean of two consecutive A series sheets. The B series was brought into being to provide a wider range of paper sizes, where as the C series is used only for envelopes. Two other ISO paper series exist-B and C. Take note that the height of A1 is equal to the width of A0. If you do this with an A0 sheet of paper, the resulting dimensions will be 594 × 841 millimeters, or the A1 format. Figuring out the dimensions of the subsequent paper sizes does not require any real mathematical strain since each ensuing size can be created by simply folding the paper in half with the crease parallel to the shortest sides. With an aspect ratio equal to the square root of two, a sheet of A0 paper ends up being 841 × 1189 millimeters. The basis for the whole system is the A0 format which has an area of one square meter. The larger that number, the smaller the paper. All paper sizes of this series have a name that consists of an A followed by a number. The most widely used paper of this series is the A4 format. The most popular series of the ISO standard is the A series. The most convenient and distinguishing characteristic of ISO paper is that each format has an aspect ratio equal to the square root of two (1:4142) which makes it simple to enlarge or reduce a document for printing on another ISO paper format. Though the sizes now begin with ANSI, they are nevertheless based on the traditional sizes. The names of North American sizes have started with ANSI ever since the adoption of ANSI/ASME Y14.1 by the American National Standards Institute in 1995. The current sizes are based on traditional sizes such as Letter (8.5 in × 11 in) and Legal (8.5 in × 14 in). The North American system is used primarily in the USA and Canada. The most commonly used ISO paper size is A4. The system became widely used during World War II. This new standard was known as the DIN 476 standard. Walter Porstmann brought Lichtenberg’s ideas into being in Germany. This idea was originally proposed by the German scientist Georg Christoph Lichtenberg in 1786. It is based on an aspect ratio of the square root of two, like the side of a square and its diagonal. They are the international and North American systems.Īs the term implies, the international standard, also known as the ISO 216 standard, is used throughout the world. Though other paper size standards exist, there are two predominant systems in use today. Note: If you have to create an annotated bibliography, it's a good idea to remove field codes and then paste your annotations in the bibliography. Otherwise, EndNote will think your notes are "errors" and will delete them when Instant Formatting is on, or when you click "Update Citations and Bibliography."ģ. Insert Citation: Insert the selected citation into your Word document.Ģ: Format Bibliography: Make edits to the bibliography in your World document. Note: Save your Word document after inserting citations.ġ. The selected references will be inserted into your Word document.
Psychonauts are what they sound like – astronauts of the mind – and can jump into the brain of anybody. It’s here where the premise of Psychonauts rears itself. But he was hired by somebody – and it’s up to Raz and his team to enter Loboto’s mind to discover just who hired him and what they want with the Psychonauts. Loboto was the antagonist of the VR game, Rhombus of Ruin, and was revealed to be the one behind capturing the head of the Psychonauts. The new assignment sees Raz entering the mind of a twisted dentist named Caligosto Loboto. As the game opens, he is assigned a new task from his superiors. After spending some time at Psychonauts Headquarters, Raz gets to a point where he realises it’s not exactly what he expected. In Psychonauts 2, like the other games, you’ll play as Raz, a Psychonaut recently inducted into the academy. That’s an eclectic mix, for sure, but it best illustrates just what a Psychonaut does. If I had to quickly and lazily compare Psychonauts to something as a concept, I’d say that it’s like Inception meets Inside Out. Still, newcomers like me can also easily catch up with a video recap that’s littered with the trademark charm I’ve come to expect from Double Fine. Fans will undoubtedly appreciate this sense of continuity. I’ve no idea what has happened in the previous games, but the game starts where those games ended. I appreciate that Psychonauts 2 from the get-go is keen to cater to its fans. I was given the opportunity to try four of the brain levels, with the first two being the game’s opening. I’ve never spent a lot of time with the original but after spending a considerable amount of time time with Psychonauts 2, I felt oddly nostalgic whilst playing it despite not playing the original. Psychonauts is one of those “blind spots” in gaming for me. Motherhood drains her – “soon all of Eve’s time was spent waiting, waiting, waiting for the day to pass” – until the new classics teacher, Gabriel Easton, and his wife, Fen, arrive. To Eve, public schools are “alien territory”, and at first she commutes to her own job in London, but when she becomes pregnant she gives it up and settles into life at Cleeve. In Laura Vaughan’s psychological thriller Hazard Night (Corvus), Eve’s husband, Peter, takes a job as a housemaster at his old, minor public school, Cleeve College, remembering his time there as “the best years” of his life. We are, together, a burnt-out ex-cop, a beautiful vet and a fairly eccentric botanist… I don’t think we should be desecrating a mausoleum”) and by the increasing sense of menace, as Jake digs into what happened to the dead girl.Ībell’s love of the genre shines through, as Jake ponders what Jack Reacher might do in a messy situation I was charmed and engrossed – by Jake’s self-reinvention, by Abell’s eccentric cast of characters (“It’s the middle of the day in a picturesque English church. What really happened to her and who can Jake really trust out here? Abell’s enjoyment of the genre shines through, as Jake ponders what the likes of Jack Reacher might do in a messy situation, and as he and Livia team up to investigate, becoming “Jackson and Bennet, the crime-fighters of Little Sky”, another of crime fiction’s detective duos. He is sucked back in, though, both by beautiful neighbour Livia Bennet and by the discovery, during a treasure hunt around the nearby village of Caelum Parvum, or Little Sky, of a young woman’s bones. So when his uncle dies, leaving him a property in the middle of nowhere, he gives it all up to begin a new life off-grid: long runs, morning swims in his private lake, minimal interaction with the world at large and time to read through his uncle’s vast library of detective novels. Jake Jackson is a washed-upcop, disillusioned with his career and his marriage. I finished it in one huge gulp, excusing myself unilaterally from any family responsibilities I was so desperate to finish it.ĭeath Under a Little Sky (HarperCollins) is journalist Stig Abell’s first novel and a joyful dive into the detective genre. In the best possible way, this is a hugely stressful read, as we watch both women slowly come to realise the truth about their situations, urging them on from the sidelines. There are shades of Before I Go to Sleep, SJ Watson’s debut novel about a woman with amnesia, in Hannah Beckerman’s The Forgetting (Lake Union), but that’s no bad thing: Beckerman gives the amnesia trope her own twist to create a compelling, claustrophobic story. “It is as though there is an impenetrable black box in my head, like the flight recorder of a crashed plane, but it is locked and tightly sealed and there is no way for me to access it.” Meanwhile, in Bristol, Livvy Nicholson has a six-month-old son, a loving new husband, Dominic, and a yearning to get back to work that is being inadvertently thwarted by Dominic’s plans for his own career. Her husband, Stephen, feels like a total stranger to her the details of her life are a mystery. A nna Bradshaw remembers nothing when she wakes in a London hospital after an accident. If the professional or commercial licenses do not fit your intended usage please contact me outlining your proposal. If you are intending to use Patterncooler downloads in commercial projects please see the license plans created to provide simple and affordable solutions to many types of requirement. Know more about this designer wallpaper collection for your house at Asian. If you are frequently making use of the FREE download options, then please consider making a donation - The project continues to rely on donations to help support ongoing development. Choose from a range of elegant & artistic wallpaper design for home from Nilaya. Printed and digital art and design projects.PhotoShop, Corel and Gimp texture and fill tiles.Twitter, Tumblr and Wordpress blog backgrounds.This simple web app has been designed to provide seamless pattern images, for the use in creating:. Unlimited large tiles over 300px x 300px* and pattern area graphics can be obtained via the new license plans. With its intricate patterns, rich colors, and versatility, it's no wonder why it remains a popular choice for designers and homeowners alike.Patterncooler 3.1 - Fun, Free and even cooler!Īpply your own colors, size and texture effects to thousands of pattern designs and download as seamless background images for FREE. It's also important to consider the space's overall style and colour palette to ensure that the wallpaper complements rather than clashes with existing decor elements.ĭamask Peel and Stick Wallpapers are a classic and timeless choice for anyone looking to add elegance and sophistication to their home decor. Smaller patterns and muted tones are excellent choices for more subtle elegance, while larger patterns and bolder colours can make a dramatic statement in a room. When choosing damask wallpaper, it's essential to consider the pattern's scale and the colours used. 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So, without much ado, browse for your ideal design from our stunning collection for a look of imperial beauty.ĭamask wallpaper is a classic and timeless choice for anyone looking to add a touch of elegance and sophistication to their home decor. Our main priority is to deliver products that are true to your personal style. Brewster RD80029 Egon Paintable Textured Vinyl Wallpaper white by Brewster Home Fashions (27) 47. Luther Sand Skull Modern Damask Wallpaper Wallpaper Bolt by Brewster Home Fashions (83) 0.96/sq ft. Our damask peel and stick wallpaper is right for your house, whether your style is conventional or a little more eclectic. Dream Of Palm Trees Blue Texture Wallpaper, Bolt by Brewster Home Fashions (8) 2.18/sq ft. Choose from our range of varied colors and patterns, both big and small, the intricate nature of the patterns is what makes it an all-time favorite. 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Although studies have argued that first-line single-agent therapy is not inferior to combined regimens in terms of overall survival (OS), 13, 14 the combined therapy regimens FOLFOX (5-FU+OX), FOXFIRI (5-FU+IRI), XELOX or CAPOX (CAP+OX), and CAPIRI (CAP+OX) remain the mainstream approaches in first-line treatment, while patients with poor performance or at low risk of deterioration are recommended to receive single-agent therapy. 9, 10, 11, 12 ChemotherapyĬurrent chemotherapy includes both single-agent therapy, which is mainly fluoropyrimidine (5-FU)-based, and multiple-agent regimens containing one or several drugs, including oxaliplatin (OX), irinotecan (IRI), and capecitabine (CAP or XELODA or XEL). Of note, in some cases, chemotherapy or radiotherapy might be applied before or after surgery as neoadjuvant or adjuvant treatment to maximally reduce and stabilize the tumor. 5, 6, 7, 8 For those patients with unresectable lesions or who are intolerant to surgery, the goal is maximum shrinkage of the tumor and suppression of further tumor spread and growth, and radiotherapy and chemotherapy are the leading strategies for controlling disease in such patients. 4 However, despite the emergence of numerous screening programs to reduce CRC incidence, nearly a quarter of CRCs are diagnosed at an advanced stage with metastases, and 20% of the remaining cases may develop metachronous metastases, which result in difficulties in curative surgical control and subsequent tumor-related deaths. Typically, the ideal CRC treatment is to achieve complete removal of the tumor and metastases, which mostly requires surgical intervention. Given the advances in primary and adjuvant treatments, the survival time in CRC has been improving. 2 Meanwhile, the 5-year survival rate for CRC is ~64%, but drops to 12% for metastatic CRC, and further investigation is still required to develop effective approaches for medical intervention. However, this trend seems to be observed only in highly developed countries. 2 According to statistics in the USA, the death rate declined by ~50% in 2016 (13.7 per 10,000 patients) compared with that in 1970 (29.2 per 10,000 patients) because of the rapid development of screening methods and improved treatment methods. In 2018, 1.8 million new CRC cases arose, and 881,000 deaths were reported, which accounted for nearly 10% of new cancer cases and deaths worldwide, 1 and the number of new cases may increase to nearly 2.5 million in 2035. This review provides an overview of existing CRC-targeted agents and their underlying mechanisms, as well as a discussion of their limitations and future trends.Ĭolorectal cancer (CRC) ranks as the second most lethal cancer and the third most prevalent malignant tumor worldwide. Guidelines worldwide are currently updating the recommended targeted drugs on the basis of the increasing number of high-quality clinical trials. Following successes with the anti-EGFR (epidermal growth factor receptor) agent cetuximab and the anti-angiogenesis agent bevacizumab, new agents blocking different critical pathways as well as immune checkpoints are emerging at an unprecedented rate. Targeted therapy is a new optional approach that has successfully prolonged overall survival for CRC patients. However, the prognosis of CRC has never been satisfying, especially for patients with metastatic lesions. Surgery and chemotherapy have long been the first choices for cancer patients. It does not store any personal data.Colorectal cancer (CRC) is among the most lethal and prevalent malignancies in the world and was responsible for nearly 881,000 cancer-related deaths in 2018. The cookie is set by the GDPR Cookie Consent plugin and is used to store whether or not user has consented to the use of cookies. The cookie is used to store the user consent for the cookies in the category "Performance". This cookie is set by GDPR Cookie Consent plugin. The cookies is used to store the user consent for the cookies in the category "Necessary". The cookie is used to store the user consent for the cookies in the category "Other. The cookie is set by GDPR cookie consent to record the user consent for the cookies in the category "Functional". The cookie is used to store the user consent for the cookies in the category "Analytics". These cookies ensure basic functionalities and security features of the website, anonymously. 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